SLC8B1

Across TCGA patient cohorts, SLC8B1 mutation is significantly associated with the RNA expression of many other genes, with 1,293 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC8B1-associated genes across cancer lineages are PPIAL4F, MLX, and SERAC1. Each is linked with SLC8B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC8B1-to-partner and partner-to-SLC8B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4F grouped by SLC8B1-low versus SLC8B1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC8B1→partner) and Y-score (partner→SLC8B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PPIAL4F →	+0.047	+2.715	.006	.005	3	2
UCEC	MLX →	+0.452	+2.856	.001	.001	3	2
UCEC	SERAC1 →	+0.386	+3.502	.005	.002	3	2
UCEC	RMDN3 →	+0.497	+2.455	<.001	.001	3	2
UCEC	STRA6 →	-1.041	-2.641	.001	<.001	3	2
HNSC	RPL23AP56 →	+0.115	+5.241	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,293 associations by consensus.

PPIAL4F by SLC8B1 expression — BLCA

Explore this box plot interactively →