SLC8B1

Across TCGA pan-cancer cohorts, SLC8B1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SLC8B1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC8B1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC8B1 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

HNSC, BLCA, and STAD are the cancer types where SLC8B1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC8B1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+0.830	<.001	11	view →
BLCA	All	All	+0.713	<.001	10	view →
STAD	Male	II,III,IV	+1.517	<.001	9	view →
COAD	Female	II,III,IV	−0.395	<.001	6	view →
CHOL	All	All	+1.242	<.001	5	view →
KICH	All	All	−0.947	<.001	5	view →
LIHC	All	All	+0.338	.002	4	view →
ESCA	All	All	+0.726	.004	2	view →
PAAD	Male	All	−0.379	.008	2	view →
PRAD	All	All	+0.270	.001	2	view →
LUAD	All	III,IV	+0.312	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SLC8B1–HNSC

Open the HNSC breakdown →