SLC8B1

Across TCGA patient cohorts, SLC8B1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SLC8B1-associated genes across cancer lineages are Lck, Syk, and Caspase-7-cleavedD198. Each is linked with SLC8B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC8B1-to-partner and partner-to-SLC8B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by SLC8B1-low versus SLC8B1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC8B1→partner) and Y-score (partner→SLC8B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Lck →	+0.422	+2.195	.003	.034	3	2
COAD	Syk →	+0.373	+2.178	.013	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.862	+2.479	.001	.010	3	2
BLCA	eEF2 →	+0.277	+3.017	.032	.019	3	1
COAD	FoxM1 →	+0.441	+2.178	.008	.035	3	1
COAD	p27_pT157 →	+0.214	+2.178	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Lck by SLC8B1 expression — COAD

Explore this box plot interactively →