SLC8A3

Across TCGA patient cohorts, SLC8A3 mutation is significantly associated with the RNA expression of many other genes, with 6,833 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC8A3-associated genes across cancer lineages are POLE2, NEDD8, and NGDN. Each is linked with SLC8A3 in more than 5 cancer types. Because this analysis shows association rather than direction, both SLC8A3-to-partner and partner-to-SLC8A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLE2 grouped by SLC8A3-low versus SLC8A3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC8A3→partner) and Y-score (partner→SLC8A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	POLE2 →	+0.500	+1.950	.003	<.001	2	6
LUSC	NEDD8 →	+0.303	+3.459	.006	.005	3	5
STAD	NGDN →	+0.453	+3.219	.003	.009	3	5
STAD	RAN →	+0.520	+3.203	.008	.009	2	6
COAD	RANP6 →	+0.415	+3.209	<.001	.009	3	5
UCEC	CNIH1 →	+0.471	+1.971	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,833 associations by consensus.

POLE2 by SLC8A3 expression — LUAD

Explore this box plot interactively →