SLC8A2

Across TCGA patient cohorts, SLC8A2 mutation is significantly associated with the RNA expression of many other genes, with 2,758 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC8A2-associated genes across cancer lineages are HMGN2P9, RN7SKP286, and RNU2-48P. Each is linked with SLC8A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC8A2-to-partner and partner-to-SLC8A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGN2P9 grouped by SLC8A2-low versus SLC8A2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC8A2→partner) and Y-score (partner→SLC8A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HMGN2P9 →	+0.078	+2.252	.001	.003	3	3
SKCM	RN7SKP286 →	+0.026	+3.723	<.001	.009	3	3
CESC	RNU2-48P →	+0.310	+7.164	<.001	<.001	3	3
ESCA	PSMB7P1 →	+0.137	+5.084	<.001	.001	3	3
ESCA	OR4C45 →	+0.339	+4.450	<.001	.009	3	3
ESCA	CHEK2P1 →	+0.232	+4.234	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,758 associations by consensus.

HMGN2P9 by SLC8A2 expression — SKCM

Explore this box plot interactively →