Across TCGA pan-cancer cohorts, SLC8A1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SLC8A1 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SLC8A1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC8A1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

PDAC, UCEC, and HNSC are the cancer types where SLC8A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.239	0.483	<.001	52	view →
UCEC	DFS	Quartile	II,III,IV	0.281	0.893	.003	32	view →
HNSC	DFS	Median	IV	0.611	0.915	.014	3	view →
GBM	DFS	Quartile	All	0.497	0.289	.032	2	view →
LUAD	DFS	Tertile	All	0.786	0.454	.033	2	view →
CCRCC	DFS	Median	All	0.819	0.651	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: SLC8A1 tumor-vs-normal RNA expression · all SLC8A1 data types