Across TCGA pan-cancer cohorts, SLC8A1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SLC8A1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC8A1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC8A1 is over-expressed in tumor, although a few such as KIRP and BLCA show the opposite, repressed pattern.
HNSC, KIRP, and BLCA are the cancer types where SLC8A1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC8A1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.