Across TCGA patient cohorts, SLC8A1 mutation is significantly associated with the RNA expression of many other genes, with 7,613 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC8A1-associated genes across cancer lineages are UHRF1, POLE2, and PGAM5. Each is linked with SLC8A1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SLC8A1-to-partner and partner-to-SLC8A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC8A1→partner) and Y-score (partner→SLC8A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.970	+2.403	<.001	<.001	3	6
LUAD	POLE2 →	+0.683	+2.070	<.001	<.001	3	6
UCEC	PGAM5 →	+0.584	+2.187	<.001	<.001	3	5
UCEC	CBARP →	+0.755	+2.392	<.001	<.001	3	5
UCEC	CENPU →	+0.748	+1.858	<.001	<.001	3	5
UCEC	MIS18A →	+0.438	+1.509	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,613 associations by consensus.

Exploration

SLC8A1 survival (RNA) · tumor vs normal (RNA) · all SLC8A1 data types