Across TCGA cell cohorts, SLC8A1 mutation is significantly associated with the RNA expression of many other genes, with 713 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC8A1-associated genes across cancer lineages are CYP4A11, OR4D2, and CFHR2. Each is linked with SLC8A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC8A1-to-partner and partner-to-SLC8A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC8A1→partner) and Y-score (partner→SLC8A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CYP4A11 →	+0.006	+4.807	<.001	.006	3	2
BLOOD_Myeloma	OR4D2 →	+0.013	+4.807	<.001	.006	3	2
CNS	CFHR2 →	+0.038	+4.357	<.001	.004	3	2
BLOOD_Lymphoma	B4GALNT2 →	+0.019	+4.339	<.001	.005	3	2
LARGE_INTESTINE	DTWD1 →	+0.605	+1.949	<.001	.002	3	2
LARGE_INTESTINE	FCGRT →	-1.994	-2.459	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 713 associations by consensus.

Exploration

SLC8A1 survival (RNA) · tumor vs normal (RNA) · all SLC8A1 data types