SLC7A8

Across TCGA patient cohorts, SLC7A8 mutation is significantly associated with the RNA expression of many other genes, with 3,713 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC7A8-associated genes across cancer lineages are TRIM60P3Y, MIR4285, and RN7SL191P. Each is linked with SLC7A8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC7A8-to-partner and partner-to-SLC7A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM60P3Y grouped by SLC7A8-low versus SLC7A8-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A8→partner) and Y-score (partner→SLC7A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRIM60P3Y →	+0.043	+8.057	<.001	.005	3	3
CESC	MIR4285 →	+0.599	+3.450	<.001	.005	3	3
COAD	RN7SL191P →	+0.381	+3.781	.005	.001	3	3
CESC	RNA5SP322 →	+0.213	+5.584	<.001	.001	3	2
CESC	RNA5SP447 →	+0.363	+4.201	<.001	.002	3	2
LUAD	MIR4314 →	+0.290	+4.584	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,713 associations by consensus.

TRIM60P3Y by SLC7A8 expression — BRCA

Explore this box plot interactively →