Across TCGA pan-cancer cohorts, SLC7A6OS mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SLC7A6OS’s most consistent transcriptional readouts.
The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SLC7A6OS mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SLC7A6OS is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.
CCRCC, LUAD, and LSCC are the cancer types where SLC7A6OS tumor–normal differential expression is most reproducible.