SLC7A3

Across TCGA patient cohorts, SLC7A3 mutation is significantly associated with the RNA expression of many other genes, with 4,899 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC7A3-associated genes across cancer lineages are NDUFV3, RRAGC, and OCIAD2. Each is linked with SLC7A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC7A3-to-partner and partner-to-SLC7A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFV3 grouped by SLC7A3-low versus SLC7A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A3→partner) and Y-score (partner→SLC7A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFV3 →	+0.228	+1.765	.003	<.001	3	3
UCEC	RRAGC →	+0.482	+3.007	<.001	<.001	3	3
UCEC	OCIAD2 →	+0.512	+2.032	<.001	.001	3	3
UCEC	SRSF9P1 →	+0.285	+1.530	.009	.004	3	3
LUAD	RNU6-633P →	+0.564	+2.656	.001	.007	3	3
SKCM	TRAV36DV7 →	+0.525	+2.613	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,899 associations by consensus.

NDUFV3 by SLC7A3 expression — UCEC

Explore this box plot interactively →