SLC7A3

Across TCGA pan-cancer cohorts, SLC7A3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SLC7A3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLC7A3 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC7A3 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and KICH are the cancer types where SLC7A3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC7A3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.254	<.001	11	view →
KIRC	All	II,III,IV	−0.224	<.001	9	view →
KICH	All	All	−0.227	<.001	7	view →
KIRP	All	All	−0.112	<.001	7	view →
BRCA	Female	All	−1.889	<.001	6	view →
UCEC	All	All	−1.686	<.001	6	view →
BLCA	All	IV	−0.651	.006	5	view →
THCA	All	All	−0.082	<.001	5	view →
STAD	All	All	−0.791	<.001	4	view →
ESCA	Female	All	−0.596	.027	1	view →
LUSC	All	All	+0.234	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SLC7A3–COAD

Open the COAD breakdown →