SLC7A3

Across TCGA patient cohorts, SLC7A3 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC7A3-associated genes across cancer lineages are mTOR_pS2448, p38-MAPK_pT180_Y182, and p62 Lck ligand. Each is linked with SLC7A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC7A3-to-partner and partner-to-SLC7A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SLC7A3-low versus SLC7A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A3→partner) and Y-score (partner→SLC7A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.139	-2.482	.004	.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.385	-1.678	.009	.021	3	2
SKCM	p62 Lck ligand →	+0.448	+2.182	.009	.033	3	2
UCEC	PCNA →	+0.217	+1.938	.002	.001	3	2
UCEC	C-Raf_pS338 →	-0.061	-1.392	.024	.019	3	2
UCEC	C-Raf →	+0.134	+1.906	.004	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

mTOR_pS2448 by SLC7A3 expression — UCEC

Explore this box plot interactively →