SLC7A3

Across TCGA cell cohorts, SLC7A3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,747 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC7A3-associated GO terms across cancer lineages are Protein-DNA complex organization, U2-type prespliceosome assembly, and Regulation of transcription initiation by RNA polymerase II. Each is linked with SLC7A3 in more than 8 cancer types. Because this analysis shows association rather than direction, both SLC7A3-to-partner and partner-to-SLC7A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-DNA complex organization grouped by SLC7A3-low versus SLC7A3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A3→partner) and Y-score (partner→SLC7A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein-DNA complex organization →	+0.098	+1.872	<.001	.003	3	9
BLOOD_Leukemia	U2-type prespliceosome assembly →	+0.039	+1.537	.009	.006	3	9
BLOOD_Leukemia	Regulation of transcription initiation by RNA polymerase II →	+0.041	+1.626	<.001	<.001	3	9
BONE	Positive regulation of DNA repair →	+0.074	+2.360	.002	<.001	2	9
BONE	Positive regulation of DNA recombination →	+0.117	+1.679	.001	.004	3	8
SOFT_TISSUE	Heterochromatin formation →	+0.070	+1.266	<.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,747 associations by consensus.

Protein-DNA complex organization by SLC7A3 expression — BONE

Explore this box plot interactively →