SLC7A3

Across TCGA cell cohorts, SLC7A3 mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC7A3-associated genes across cancer lineages are SLC17A2, PNLIPRP1, and HTR3B. Each is linked with SLC7A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC7A3-to-partner and partner-to-SLC7A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC17A2 grouped by SLC7A3-low versus SLC7A3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A3→partner) and Y-score (partner→SLC7A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC17A2 →	+0.012	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	PNLIPRP1 →	+0.033	+4.947	<.001	.001	3	1
CNS	HTR3B →	+0.361	+4.981	<.001	.008	3	1
CNS	DEFB132 →	+0.432	+5.321	<.001	.005	3	1
LARGE_INTESTINE	MAPK8 →	+0.850	+3.215	<.001	.009	3	1
LARGE_INTESTINE	LRRC42 →	+0.730	+3.125	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

SLC17A2 by SLC7A3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →