SLC7A2

Across TCGA patient cohorts, SLC7A2 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC7A2-associated genes across cancer lineages are PCNA, ATM, and GAPDH. Each is linked with SLC7A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC7A2-to-partner and partner-to-SLC7A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SLC7A2-low versus SLC7A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A2→partner) and Y-score (partner→SLC7A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.261	+1.893	<.001	<.001	3	3
COAD	ATM →	-0.604	-2.991	.002	.036	3	3
SKCM	GAPDH →	+0.651	+3.000	.025	.034	3	2
UCEC	EGFR_pY1068 →	-0.216	-1.643	.005	.003	3	2
UCEC	FoxM1 →	+0.165	+1.893	.040	<.001	3	2
UCEC	INPP4B →	-0.241	-2.169	.016	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

PCNA by SLC7A2 expression — UCEC

Explore this box plot interactively →