SLC7A2

Across TCGA pan-cancer cohorts, SLC7A2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SLC7A2 data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher SLC7A2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLC7A2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UVM show a favorable association.

STAD, HNSC, and ACC are the cancer types where SLC7A2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Quartile	All	0.323	0.583	<.001	114	view →
HNSC	DFS	Median	IV	0.633	0.446	<.001	77	view →
ACC	OS	Median	II,III,IV	0.742	0.967	.001	54	view →
BLCA	DFS	Median	All	0.366	0.595	.002	38	view →
UVM	OS	Quartile	II,III,IV	0.832	0.375	.001	36	view →
KIRP	OS	Quartile	All	0.678	0.916	<.001	36	view →
SKCM	OS	Median	All	0.270	0.385	.004	34	view →
BRCA	DFS	Tertile	III,IV	0.922	0.790	.001	27	view →
MESO	OS	Tertile	II,III,IV	0.696	0.422	.011	22	view →
SCLC	DFS	Quartile	All	0.152	0.565	<.001	20	view →
UCEC	DFS	Median	All	0.795	0.874	.004	20	view →
READ	DFS	Median	All	0.278	0.727	.011	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SLC7A2–STAD (OS)

Open the STAD breakdown →