SLC7A2

Across TCGA cell cohorts, SLC7A2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC7A2-associated genes across cancer lineages are PRAMEF12, OR4C12, and SCN2A. Each is linked with SLC7A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC7A2-to-partner and partner-to-SLC7A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF12 grouped by SLC7A2-low versus SLC7A2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A2→partner) and Y-score (partner→SLC7A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRAMEF12 →	+0.066	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.017	+4.662	<.001	.005	3	1
LARGE_INTESTINE	SCN2A →	+0.463	+3.658	<.001	.003	3	1
LARGE_INTESTINE	OR4F21 →	+0.155	+2.878	<.001	.009	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	ELANE →	+0.417	+3.404	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PRAMEF12 by SLC7A2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →