SLC7A14

Across TCGA patient cohorts, SLC7A14 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC7A14-associated genes across cancer lineages are Caspase-7-cleavedD198, mTOR_pS2448, and IRS1. Each is linked with SLC7A14 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC7A14-to-partner and partner-to-SLC7A14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SLC7A14-low versus SLC7A14-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A14→partner) and Y-score (partner→SLC7A14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+0.975	+3.000	.011	.036	2	4
UCEC	mTOR_pS2448 →	-0.124	-2.074	.006	.004	3	3
SKCM	IRS1 →	+0.182	+2.186	.001	.032	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.430	-1.925	.001	.004	3	2
SKCM	4E-BP1_pT37_T46 →	-0.577	-2.906	<.001	.001	3	2
UCEC	Caspase-8 →	-0.271	-1.947	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Caspase-7-cleavedD198 by SLC7A14 expression — STAD

Explore this box plot interactively →