SLC7A14

Across TCGA pan-cancer cohorts, SLC7A14 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SLC7A14 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SLC7A14 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SLC7A14 expression acts as an unfavorable survival marker, although some lineages such as ACC and LGG show a favorable association.

ACC, KIRP, and KIRC are the cancer types where SLC7A14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.846	0.411	<.001	89	view →
KIRP	OS	Tertile	All	0.584	0.823	<.001	88	view →
KIRC	OS	Median	All	0.549	0.709	.001	66	view →
THCA	OS	Tertile	III,IV	0.880	0.987	.004	57	view →
LGG	DFS	Median	All	0.499	0.308	<.001	51	view →
READ	DFS	Tertile	All	0.446	0.952	.005	36	view →
UVM	DFS	Tertile	All	0.446	0.920	.003	31	view →
PAAD	DFS	Tertile	All	0.392	0.175	.004	28	view →
DLBC	DFS	Median	IV	0.136	0.817	.002	27	view →
MESO	DFS	Tertile	All	0.649	0.227	.029	18	view →
BLCA	OS	Median	All	0.523	0.379	.023	15	view →
LIHC	OS	Median	III,IV	0.276	0.627	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SLC7A14–ACC (OS)

Open the ACC breakdown →