SLC7A13

Across TCGA patient cohorts, SLC7A13 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC7A13-associated genes across cancer lineages are A-Raf_pS299, mTOR_pS2448, and p38-MAPK_pT180_Y182. Each is linked with SLC7A13 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC7A13-to-partner and partner-to-SLC7A13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by SLC7A13-low versus SLC7A13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A13→partner) and Y-score (partner→SLC7A13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.091	-1.700	.038	.042	3	2
UCEC	mTOR_pS2448 →	-0.125	-1.787	.022	.026	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.444	-1.834	.007	.008	3	2
UCEC	PDCD4 →	-0.714	-2.247	<.001	.001	3	2
UCEC	STAT3_pY705 →	-0.341	-1.678	<.001	.019	3	2
UCEC	TFRC →	+0.678	+2.906	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

A-Raf_pS299 by SLC7A13 expression — UCEC

Explore this box plot interactively →