SLC7A11

Across TCGA patient cohorts, SLC7A11 mutation is significantly associated with the RNA expression of many other genes, with 5,465 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC7A11-associated genes across cancer lineages are CUEDC1, RN7SKP286, and RNF19BPY. Each is linked with SLC7A11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC7A11-to-partner and partner-to-SLC7A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CUEDC1 grouped by SLC7A11-low versus SLC7A11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A11→partner) and Y-score (partner→SLC7A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CUEDC1 →	+0.584	+3.372	.001	.004	3	2
SKCM	RN7SKP286 →	+0.033	+4.110	<.001	.005	3	2
ESCA	RNF19BPY →	+0.020	+5.068	.003	.008	3	2
UCEC	RPS29P32 →	+0.274	+1.899	<.001	.002	3	2
UCEC	FBXO7 →	+0.481	+2.557	<.001	<.001	3	2
UCEC	RPL23AP82 →	+0.557	+2.917	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,465 associations by consensus.

CUEDC1 by SLC7A11 expression — SKCM

Explore this box plot interactively →