SLC7A11

Across TCGA pan-cancer cohorts, SLC7A11 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SLC7A11’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLC7A11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC7A11 is over-expressed in tumor.

COAD, HNSC, and KIRC are the cancer types where SLC7A11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC7A11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+2.028	<.001	11	view →
HNSC	Male	All	+2.112	<.001	10	view →
KIRC	Male	All	+0.741	<.001	10	view →
KIRP	All	II,III,IV	+2.644	<.001	9	view →
KICH	Male	II,III,IV	+1.941	<.001	9	view →
LUSC	Male	II,III,IV	+2.516	<.001	8	view →
LUAD	All	II,III,IV	+2.056	<.001	8	view →
LIHC	Male	II,III,IV	+1.979	<.001	8	view →
PAAD	All	All	+2.037	<.001	6	view →
BRCA	All	II,III,IV	+0.911	<.001	6	view →
STAD	All	II,III,IV	+1.436	<.001	5	view →
READ	All	All	+1.486	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SLC7A11–COAD

Open the COAD breakdown →