SLC7A11

Across TCGA patient cohorts, SLC7A11 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC7A11-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Caspase-7-cleavedD198, and Dvl3. Each is linked with SLC7A11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC7A11-to-partner and partner-to-SLC7A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by SLC7A11-low versus SLC7A11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A11→partner) and Y-score (partner→SLC7A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.381	-1.638	.010	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.644	+2.189	<.001	.001	3	2
UCEC	Dvl3 →	+0.140	+1.502	.020	.027	3	2
UCEC	14-3-3_beta →	-0.125	-2.249	<.001	<.001	3	1
UCEC	eEF2 →	+0.379	+2.700	.001	.005	3	1
UCEC	eIF4E →	+0.209	+3.920	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

p38-MAPK_pT180_Y182 by SLC7A11 expression — UCEC

Explore this box plot interactively →