SLC7A11

Across TCGA cell cohorts, SLC7A11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,219 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SLC7A11-associated GO terms across cancer lineages are L-cystine transport, Lysosomal lumen pH elevation, and L-glutamate import. Each is linked with SLC7A11 in more than 17 cancer types. Because this analysis shows association rather than direction, both SLC7A11-to-partner and partner-to-SLC7A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-cystine transport grouped by SLC7A11-low versus SLC7A11-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A11→partner) and Y-score (partner→SLC7A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	L-cystine transport →	+1.262	+2.456	<.001	<.001	3	18
LUNG_SCLC	Lysosomal lumen pH elevation →	+0.279	+1.420	.002	<.001	3	16
LIVER	L-glutamate import →	+0.157	+2.778	<.001	.001	3	13
BONE	Intracellular pH elevation →	+0.263	+2.229	<.001	<.001	3	12
OVARY	Sulfur amino acid transport →	+0.210	+2.146	<.001	<.001	3	12
BLOOD_Lymphoma	Phenylalanine transport →	+0.193	+1.333	.002	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,219 associations by consensus.

L-cystine transport by SLC7A11 expression — PANCREAS

Explore this box plot interactively →