SLC7A11

Across TCGA cell cohorts, SLC7A11 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC7A11-associated genes across cancer lineages are OPN1MW, SH3GL2, and OCIAD1. Each is linked with SLC7A11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC7A11-to-partner and partner-to-SLC7A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPN1MW grouped by SLC7A11-low versus SLC7A11-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A11→partner) and Y-score (partner→SLC7A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OPN1MW →	+0.027	+4.357	<.001	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.940	+3.667	<.001	<.001	3	1
LARGE_INTESTINE	OCIAD1 →	+0.512	+3.125	.002	.008	3	1
LARGE_INTESTINE	UFSP2 →	+0.736	+3.082	<.001	.007	3	1
LARGE_INTESTINE	SCGB2A1 →	+0.618	+3.392	<.001	.006	3	1
LARGE_INTESTINE	ATP5F1A →	+0.876	+3.082	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

OPN1MW by SLC7A11 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →