SLC6A7

Across TCGA patient cohorts, SLC6A7 mutation is significantly associated with the RNA expression of many other genes, with 1,041 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A7-associated genes across cancer lineages are NOP2, KRT8P49, and RNU6-548P. Each is linked with SLC6A7 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC6A7-to-partner and partner-to-SLC6A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOP2 grouped by SLC6A7-low versus SLC6A7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A7→partner) and Y-score (partner→SLC6A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NOP2 →	+0.333	+3.604	.009	.001	3	3
UCEC	KRT8P49 →	+0.240	+2.669	<.001	.004	3	2
SKCM	RNU6-548P →	+0.604	+2.402	.001	.005	3	2
CESC	NMD3P2 →	+0.047	+5.010	.001	.009	3	2
SKCM	ATP5MD →	+0.367	+3.208	.004	.009	3	2
SKCM	FCER1A →	-0.675	-3.559	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,041 associations by consensus.

NOP2 by SLC6A7 expression — SKCM

Explore this box plot interactively →