SLC6A6

Across TCGA cell cohorts, SLC6A6 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SLC6A6-associated genes across cancer lineages are ACSM2A, AVP, and OR1J2. Each is linked with SLC6A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A6-to-partner and partner-to-SLC6A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM2A grouped by SLC6A6-low versus SLC6A6-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A6→partner) and Y-score (partner→SLC6A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ACSM2A →	+0.022	+5.000	<.001	.006	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR1J2 →	+0.124	+3.343	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR1J4 →	+0.218	+3.518	<.001	.008	3	1
LARGE_INTESTINE	NTRK1 →	+0.698	+3.464	.001	.004	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ACSM2A by SLC6A6 expression — PANCREAS

Explore this box plot interactively →