SLC6A4

Across TCGA cell cohorts, SLC6A4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible SLC6A4-associated genes across cancer lineages are BANF2, OR2D3, and OR2H1. Each is linked with SLC6A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A4-to-partner and partner-to-SLC6A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BANF2 grouped by SLC6A4-low versus SLC6A4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A4→partner) and Y-score (partner→SLC6A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BANF2 →	+0.035	+4.643	.003	.005	3	1
OVARY	OR2D3 →	+0.028	+3.990	<.001	.003	3	1
OVARY	OR2H1 →	+0.023	+4.444	<.001	.001	3	1
OVARY	OR2J3 →	+0.017	+3.938	.004	.005	3	1
LARGE_INTESTINE	IL20 →	+0.275	+3.662	<.001	.009	2	1
BLOOD_Lymphoma	FAM110D →	+0.128	+4.350	<.001	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

BANF2 by SLC6A4 expression — BLOOD_Lymphoma

Explore this box plot interactively →