SLC6A2

Across TCGA cell cohorts, SLC6A2 mutation is significantly associated with the RNA expression of many other genes, with 101 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC6A2-associated genes across cancer lineages are USP14, RASA4, and STXBP3. Each is linked with SLC6A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A2-to-partner and partner-to-SLC6A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP14 grouped by SLC6A2-low versus SLC6A2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A2→partner) and Y-score (partner→SLC6A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	USP14 →	+0.650	+3.451	.004	.002	3	1
LARGE_INTESTINE	RASA4 →	-0.982	-3.278	.004	.006	3	1
LARGE_INTESTINE	STXBP3 →	+0.476	+3.364	.003	.002	3	1
LARGE_INTESTINE	MLH3 →	+0.623	+3.364	.001	.002	3	1
LARGE_INTESTINE	NUP43 →	+0.563	+3.364	.002	.002	3	1
LARGE_INTESTINE	C12orf65 →	+0.423	+3.364	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

USP14 by SLC6A2 expression — LARGE_INTESTINE

Explore this box plot interactively →