SLC6A18

Across TCGA patient cohorts, SLC6A18 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A18-associated genes across cancer lineages are eEF2, ERK2, and Ku80. Each is linked with SLC6A18 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC6A18-to-partner and partner-to-SLC6A18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SLC6A18-low versus SLC6A18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A18→partner) and Y-score (partner→SLC6A18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.494	+3.321	.001	.010	3	3
UCEC	ERK2 →	+0.198	+3.169	.015	.018	3	2
UCEC	Ku80 →	+0.306	+2.920	.002	.001	3	2
UCEC	MEK1 →	+0.359	+2.584	.020	.010	3	2
UCEC	14-3-3_beta →	-0.097	-3.143	.022	.018	3	1
UCEC	EGFR_pY1068 →	-0.243	-2.222	.022	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eEF2 by SLC6A18 expression — UCEC

Explore this box plot interactively →