SLC6A18

Across TCGA pan-cancer cohorts, SLC6A18 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SLC6A18’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SLC6A18 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC6A18 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and COAD are the cancer types where SLC6A18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC6A18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−3.231	<.001	10	view →
KIRP	All	All	−2.013	<.001	7	view →
COAD	All	All	−0.157	.010	4	view →
STAD	All	All	+0.071	.008	2	view →
LUSC	Male	All	−0.023	.025	2	view →
LIHC	All	II,III,IV	+0.005	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SLC6A18–KICH

Open the KICH breakdown →