SLC6A16

Across TCGA patient cohorts, SLC6A16 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A16-associated genes across cancer lineages are ATM, HER2_pY1248, and PRDX1. Each is linked with SLC6A16 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC6A16-to-partner and partner-to-SLC6A16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SLC6A16-low versus SLC6A16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A16→partner) and Y-score (partner→SLC6A16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.725	-2.906	<.001	.001	3	3
SKCM	HER2_pY1248 →	-0.148	-3.000	.019	.034	3	2
SKCM	PRDX1 →	+0.284	+2.321	.026	.033	3	2
UCEC	Cyclin-B1 →	+0.708	+3.000	.002	.036	3	2
UCEC	JNK2 →	+0.261	+1.700	.001	.044	3	2
UCEC	Notch1 →	+0.210	+3.331	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ATM by SLC6A16 expression — UCEC

Explore this box plot interactively →