SLC6A14

Across TCGA cell cohorts, SLC6A14 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC6A14-associated genes across cancer lineages are AQP8, OCM, and DNAI2. Each is linked with SLC6A14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A14-to-partner and partner-to-SLC6A14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP8 grouped by SLC6A14-low versus SLC6A14-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A14→partner) and Y-score (partner→SLC6A14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AQP8 →	+0.025	+4.029	.007	.002	3	1
SKIN	OCM →	+0.257	+3.758	<.001	.004	3	1
SKIN	DNAI2 →	+0.141	+3.196	.001	.007	3	1
BLOOD_Lymphoma	BANF2 →	+0.057	+4.058	<.001	.009	3	1
LARGE_INTESTINE	DEUP1 →	+0.430	+3.569	<.001	.006	2	2
BLOOD_Lymphoma	OR10W1 →	+0.019	+4.058	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

AQP8 by SLC6A14 expression — SKIN

Explore this box plot interactively →