SLC6A13

Across TCGA patient cohorts, SLC6A13 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A13-associated genes across cancer lineages are 4E-BP1, eIF4E, and MYH11. Each is linked with SLC6A13 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC6A13-to-partner and partner-to-SLC6A13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SLC6A13-low versus SLC6A13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A13→partner) and Y-score (partner→SLC6A13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.356	+1.955	<.001	.002	3	4
UCEC	eIF4E →	+0.190	+2.523	.008	<.001	3	2
SKCM	MYH11 →	-0.696	-1.415	.030	.045	3	2
UCEC	IGFBP2 →	-0.479	-1.874	.030	.049	3	2
UCEC	mTOR →	-0.118	-1.247	.031	.045	3	2
UCEC	ATM →	-0.633	-2.893	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

4E-BP1 by SLC6A13 expression — UCEC

Explore this box plot interactively →