SLC6A12

Across TCGA patient cohorts, SLC6A12 mutation is significantly associated with the RNA expression of many other genes, with 2,312 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A12-associated genes across cancer lineages are ELAC2, RPL23AP82, and MARS1. Each is linked with SLC6A12 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC6A12-to-partner and partner-to-SLC6A12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELAC2 grouped by SLC6A12-low versus SLC6A12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A12→partner) and Y-score (partner→SLC6A12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ELAC2 →	+0.478	+2.155	<.001	.009	3	3
UCEC	RPL23AP82 →	+0.524	+2.332	<.001	<.001	3	3
UCEC	MARS1 →	+0.451	+2.946	<.001	<.001	3	3
SKCM	ENO1 →	+0.557	+3.484	.001	.002	3	3
UCEC	MRPS18A →	+0.451	+2.354	.004	.003	3	3
UCEC	GOT1 →	+0.474	+2.871	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,312 associations by consensus.

ELAC2 by SLC6A12 expression — UCEC

Explore this box plot interactively →