SLC6A12

Across TCGA patient cohorts, SLC6A12 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A12-associated genes across cancer lineages are ATM, ASNS, and eIF4E. Each is linked with SLC6A12 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC6A12-to-partner and partner-to-SLC6A12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SLC6A12-low versus SLC6A12-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A12→partner) and Y-score (partner→SLC6A12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.840	-3.000	<.001	.035	3	3
COAD	ASNS →	+0.615	+3.178	.001	.010	3	2
UCEC	eIF4E →	+0.203	+2.502	.014	.002	3	2
UCEC	MSH2 →	-0.289	-3.433	.001	.005	3	2
UCEC	Akt_pT308 →	+0.666	+3.459	.007	.005	3	2
UCEC	PCNA →	+0.194	+2.459	.022	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ATM by SLC6A12 expression — COAD

Explore this box plot interactively →