SLC6A11

Across TCGA patient cohorts, SLC6A11 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A11-associated genes across cancer lineages are S6_pS240_S244, TFRC, and Caspase-7-cleavedD198. Each is linked with SLC6A11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A11-to-partner and partner-to-SLC6A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by SLC6A11-low versus SLC6A11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A11→partner) and Y-score (partner→SLC6A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.399	+1.584	.003	.009	3	2
UCEC	TFRC →	+0.422	+1.584	.017	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.583	+2.189	.003	.001	3	2
SKCM	HER3 →	+0.340	+1.700	.031	.040	3	1
UCEC	eIF4G →	+0.246	+2.459	.017	.018	3	1
UCEC	FASN →	+0.282	+1.584	.033	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

S6_pS240_S244 by SLC6A11 expression — UCEC

Explore this box plot interactively →