SLC6A11

Across TCGA cell cohorts, SLC6A11 mutation is significantly associated with the RNA expression of many other genes, with 426 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC6A11-associated genes across cancer lineages are MAGEB5, MRLN, and CRYGD. Each is linked with SLC6A11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A11-to-partner and partner-to-SLC6A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by SLC6A11-low versus SLC6A11-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A11→partner) and Y-score (partner→SLC6A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LIVER	MRLN →	+0.223	+3.977	.001	.006	3	1
SKIN	CRYGD →	+0.418	+4.415	<.001	.007	3	1
SKIN	C1orf141 →	+0.027	+4.467	<.001	.004	3	1
CNS	UGT2B10 →	+0.036	+4.321	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRTAP21-1 →	+0.020	+4.681	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 426 associations by consensus.

MAGEB5 by SLC6A11 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →