SLC66A3

Across TCGA cell cohorts, SLC66A3 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC66A3-associated genes across cancer lineages are NT5C1A, CLDN17, and LRRC52. Each is linked with SLC66A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC66A3-to-partner and partner-to-SLC66A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NT5C1A grouped by SLC66A3-low versus SLC66A3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC66A3→partner) and Y-score (partner→SLC66A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NT5C1A →	+0.057	+4.684	<.001	.002	3	1
LARGE_INTESTINE	CLDN17 →	+0.064	+4.930	<.001	.001	3	1
LARGE_INTESTINE	LRRC52 →	+0.037	+4.415	<.001	.007	3	1
LARGE_INTESTINE	HTR1E →	+0.066	+4.930	<.001	.001	3	1
LARGE_INTESTINE	OR10H2 →	+0.151	+4.273	<.001	.006	3	1
LARGE_INTESTINE	GPR171 →	+0.019	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

NT5C1A by SLC66A3 expression — LARGE_INTESTINE

Explore this box plot interactively →