SLC66A1

Across TCGA patient cohorts, SLC66A1 mutation is significantly associated with the RNA expression of many other genes, with 430 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC66A1-associated genes across cancer lineages are PKN3, ALKBH5, and NUP50. Each is linked with SLC66A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC66A1-to-partner and partner-to-SLC66A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKN3 grouped by SLC66A1-low versus SLC66A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC66A1→partner) and Y-score (partner→SLC66A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKN3 →	+1.076	+3.595	<.001	.001	3	2
UCEC	ALKBH5 →	+0.514	+3.532	.005	.002	3	2
UCEC	NUP50 →	+0.514	+3.584	.006	.003	3	2
UCEC	XXYLT1-AS2 →	+0.295	+3.346	.008	.005	3	2
UCEC	MED31 →	+0.467	+3.617	.006	.001	3	2
UCEC	GCH1 →	+0.758	+3.617	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 430 associations by consensus.

PKN3 by SLC66A1 expression — UCEC

Explore this box plot interactively →