SLC66A1

Across TCGA pan-cancer cohorts, SLC66A1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SLC66A1 data layer compared with 4 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SLC66A1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLC66A1 expression acts as an unfavorable survival marker, although some lineages such as COAD and SCLC show a favorable association.

LIHC, KICH, and KIRC are the cancer types where SLC66A1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.602	0.770	<.001	94	view →
KICH	OS	Tertile	All	0.534	1.000	.001	80	view →
KIRC	DFS	Quartile	II,III,IV	0.730	0.878	.001	72	view →
LGG	DFS	Median	All	0.605	0.869	<.001	54	view →
COAD	DFS	Median	II,III,IV	0.637	0.341	<.001	49	view →
BLCA	OS	Median	III,IV	0.106	0.428	<.001	37	view →
ACC	DFS	Quartile	All	0.202	0.754	.001	36	view →
LAML	DFS	Tertile	All	0.411	0.664	.004	30	view →
SARC	OS	Quartile	All	0.769	0.933	.008	14	view →
GBM	OS	Quartile	All	0.279	0.489	.020	12	view →
STAD	DFS	Tertile	IV	0.171	0.805	.020	12	view →
LUSC	DFS	Median	III,IV	0.562	0.752	.022	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SLC66A1–LIHC (OS)

Open the LIHC breakdown →