SLC66A1

Across TCGA cell cohorts, SLC66A1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC66A1-associated genes across cancer lineages are SLC5A5, TKTL2, and MSGN1. Each is linked with SLC66A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC66A1-to-partner and partner-to-SLC66A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC5A5 grouped by SLC66A1-low versus SLC66A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC66A1→partner) and Y-score (partner→SLC66A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC5A5 →	+0.369	+3.453	<.001	.009	3	1
LARGE_INTESTINE	TKTL2 →	+0.054	+4.187	<.001	.002	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PPP1R42 →	+0.095	+3.781	.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SLC5A5 by SLC66A1 expression — LARGE_INTESTINE

Explore this box plot interactively →