SLC5A5

Across TCGA cell cohorts, SLC5A5 mutation is significantly associated with the RNA expression of many other genes, with 826 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC5A5-associated genes across cancer lineages are FAM180A, SCML2, and NLRP2B. Each is linked with SLC5A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC5A5-to-partner and partner-to-SLC5A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM180A grouped by SLC5A5-low versus SLC5A5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC5A5→partner) and Y-score (partner→SLC5A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM180A →	+0.056	+4.321	<.001	.002	3	2
LARGE_INTESTINE	SCML2 →	+1.009	+3.212	.005	.006	3	2
LARGE_INTESTINE	NLRP2B →	+0.075	+2.455	.005	.005	3	2
PANCREAS	UGT2B10 →	+0.402	+5.000	<.001	.006	3	1
SOFT_TISSUE	KRTAP5-11 →	+0.030	+5.977	<.001	.001	3	1
LUNG_SCLC	SPATA31A5 →	+0.013	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 826 associations by consensus.

FAM180A by SLC5A5 expression — BLOOD_Leukemia

Explore this box plot interactively →