SLC5A5

Across TCGA pan-cancer cohorts, SLC5A5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SLC5A5 data layer compared with 6 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SLC5A5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC5A5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UVM show a favorable association.

KIRC, STAD, and ACC are the cancer types where SLC5A5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	II,III,IV	0.392	0.644	<.001	121	view →
STAD	DFS	Tertile	All	0.474	0.709	<.001	78	view →
ACC	DFS	Median	All	0.269	0.651	<.001	76	view →
HNSC	OS	Quartile	IV	0.472	0.244	.005	71	view →
UVM	OS	Quartile	II,III,IV	0.837	0.414	.003	48	view →
LAML	DFS	Median	All	0.422	0.721	.002	36	view →
OV	DFS	Median	III,IV	0.197	0.119	.008	34	view →
THCA	OS	Quartile	II,III,IV	0.960	1.000	.007	20	view →
TGCT	DFS	Tertile	All	0.599	0.860	.002	18	view →
THYM	DFS	Quartile	II,III,IV	0.455	0.900	.006	15	view →
KIRP	DFS	Median	All	0.579	0.931	.003	15	view →
SCLC	DFS	Median	II,III,IV	0.710	0.474	.021	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SLC5A5–KIRC (DFS)

Open the KIRC breakdown →