SLC5A4

Across TCGA patient cohorts, SLC5A4 mutation is significantly associated with the RNA expression of many other genes, with 3,677 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC5A4-associated genes across cancer lineages are TOPORS, HAUS1, and UBAP1. Each is linked with SLC5A4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC5A4-to-partner and partner-to-SLC5A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOPORS grouped by SLC5A4-low versus SLC5A4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC5A4→partner) and Y-score (partner→SLC5A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TOPORS →	+0.747	+3.328	.007	.005	3	3
UCEC	HAUS1 →	+0.510	+3.928	<.001	<.001	3	3
UCEC	UBAP1 →	+0.444	+2.378	<.001	<.001	3	3
UCEC	CEP295 →	+0.451	+3.860	<.001	<.001	3	3
UCEC	GOLGA2 →	+0.420	+2.378	<.001	<.001	3	3
CESC	MIR7-3 →	+0.218	+4.757	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,677 associations by consensus.

TOPORS by SLC5A4 expression — SKCM

Explore this box plot interactively →