SLC5A4

Across TCGA pan-cancer cohorts, SLC5A4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SLC5A4 data layer compared with 11 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SLC5A4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC5A4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRP, COAD, and KIRC are the cancer types where SLC5A4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.782	0.916	<.001	96	view →
COAD	OS	Quartile	IV	0.238	0.745	<.001	93	view →
KIRC	OS	Tertile	All	0.923	0.819	<.001	61	view →
HNSC	DFS	Tertile	II,III,IV	0.459	0.280	.006	61	view →
MESO	OS	Tertile	All	0.275	0.555	<.001	46	view →
LUAD	OS	Quartile	II,III,IV	0.634	0.447	.011	23	view →
UVM	DFS	Tertile	All	0.285	0.605	.012	19	view →
UCEC	OS	Median	All	0.839	0.901	.013	18	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	18	view →
BLCA	OS	Tertile	IV	0.118	0.433	.011	17	view →
UCS	DFS	Tertile	IV	0.906	0.342	.024	12	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SLC5A4–KIRP (DFS)

Open the KIRP breakdown →