SLC5A4

Across TCGA patient cohorts, SLC5A4 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC5A4-associated genes across cancer lineages are p38-MAPK_pT180_Y182, MEK1, and p27. Each is linked with SLC5A4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC5A4-to-partner and partner-to-SLC5A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by SLC5A4-low versus SLC5A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC5A4→partner) and Y-score (partner→SLC5A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.347	-2.115	.035	.017	3	3
UCEC	MEK1 →	+0.342	+2.459	.011	.018	3	2
UCEC	p27 →	+0.231	+2.415	.004	.003	3	2
UCEC	Src_pY416 →	-0.177	-1.584	.045	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.685	+2.242	.001	.005	3	2
UCEC	Caspase-8 →	-0.298	-3.087	.001	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

p38-MAPK_pT180_Y182 by SLC5A4 expression — UCEC

Explore this box plot interactively →