SLC5A4

Across TCGA cell cohorts, SLC5A4 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC5A4-associated genes across cancer lineages are KRTAP10-4, PGK2, and OR10D3. Each is linked with SLC5A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC5A4-to-partner and partner-to-SLC5A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-4 grouped by SLC5A4-low versus SLC5A4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC5A4→partner) and Y-score (partner→SLC5A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRTAP10-4 →	+0.036	+2.923	.005	.004	3	2
URINARY_TRACT	PGK2 →	+0.052	+4.584	<.001	.002	3	1
URINARY_TRACT	OR10D3 →	+0.107	+4.087	.002	.009	3	1
URINARY_TRACT	DAZ4 →	+0.010	+4.087	<.001	.009	3	1
LUNG_SCLC	DEFB125 →	+0.086	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	ASB15 →	+0.790	+3.843	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

KRTAP10-4 by SLC5A4 expression — LARGE_INTESTINE

Explore this box plot interactively →